| Identification | Back Directory | [Name]
1H-Isoindole-4-carbonitrile, 2-[[4-[(2,6-dichlorophenyl)thio]-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-pyridinyl]carbonyl]-2,3-dihydro- | [CAS]
2763260-39-3 | [Synonyms]
1H-Isoindole-4-carbonitrile, 2-[[4-[(2,6-dichlorophenyl)thio]-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-pyridinyl]carbonyl]-2,3-dihydro- | [Molecular Formula]
C22H12Cl2F3N3O2S | [MOL File]
2763260-39-3.mol | [Molecular Weight]
510.32 |
| Chemical Properties | Back Directory | [Boiling point ]
632.1±55.0 °C(Predicted) | [density ]
1.62±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
5.41±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation[1]. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with >1500-fold cooperativity, surpassing the affinity of wild-type doubly-phosphorylated peptide. NRX-252114 further enhances the ubiquitylation of pSer33/S37A β-catenin peptide to form long ubiquitin chains[1].
The non-phosphorylated Ser33/Ser37 peptide binds β-TrCP with very weak affinity (>100 μM); however, in the presence of 20 μM NRX-252114 that binding affinity is enhanced to 180 nM. NRX-252114 also potentiates the ubiquitylation of unphosphorylated Ser33/S37A β-catenin peptides by the SCFβ-TrCP complex[1]. |
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ChemShuttle, Inc.
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0510-83588313-802 18800520310; |
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https://www.jiehuapharma.com/ |
| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
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https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
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