| Identification | Back Directory | [Name]
3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]- | [CAS]
2765218-56-0 | [Synonyms]
3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]- | [Molecular Formula]
C16H15N3O2S | [MOL File]
2765218-56-0.mol | [Molecular Weight]
313.37 |
| Chemical Properties | Back Directory | [Boiling point ]
559.1±45.0 °C(Predicted) | [density ]
1.266±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.06±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
PY-60 is a novel activator of YAP, promoting expansion of epidermal keratinocytes ex vivo and in vivo, targeting ANXA2 to activate YAP, activating a robust, YAP- dependent transcriptional program in multiple cell types. Chemical proteomics revealed the relevant target of PY-60 to be annexin A2 (ANXA2), a protein that directly associates with YAP at the cell membrane in response to increased cell density. PY-60 treatment liberates ANXA2 from the membrane, ultimately promoting a phosphatase-bound, nonphosphorylated and transcriptionally active form of YAP. |
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| Company Name: |
Shanghai Bank Pharma Limited
|
| Tel: |
021-2221346380 021-54220652 17701603001 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList20106/0.htm |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
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