| Identification | Back Directory | [Name]
2H-Indol-2-one, 3-(4,4-difluoro-1-piperidinyl)-1,3-dihydro-3-(4-hydroxyphenyl)-7-(trifluoromethyl)-, (3R)- | [CAS]
2768139-76-8 | [Synonyms]
2H-Indol-2-one, 3-(4,4-difluoro-1-piperidinyl)-1,3-dihydro-3-(4-hydroxyphenyl)-7-(trifluoromethyl)-, (3R)- | [Molecular Formula]
C20H17F5N2O2 | [MOL File]
2768139-76-8.mol | [Molecular Weight]
412.35 |
| Chemical Properties | Back Directory | [Boiling point ]
485.1±45.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
9?+-.0.30(Predicted) | [color ]
White to pink |
| Hazard Information | Back Directory | [Biological Activity]
ErSO-DFP is an anticipatory unfolded protein response (a-UPR) activator. ErSO-DFP has enhanced selectivity for estrogen receptor alpha-positive (ERα+) cancer cells with a wider selectivity window than ErSO.ErSO-DFP displays antitumor activity and leads to profound regression of MCF-7 tumors in mice model[1]. | [References]
[1]. Matthew W Boudreau, et al. Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. J Med Chem. 2022 Mar 10;65(5):3894-3912. |
|
|