| Identification | Back Directory | [Name]
Boronic acid, B-[(1R)-1-[[(2S)-2-[(2,6-difluorobenzoyl)amino]-1-oxo-3-phenylpropyl]amino]-3-methylbutyl]- | [CAS]
2806031-94-5 | [Synonyms]
Boronic acid, B-[(1R)-1-[[(2S)-2-[(2,6-difluorobenzoyl)amino]-1-oxo-3-phenylpropyl]amino]-3-methylbutyl]- | [Molecular Formula]
C21H25BF2N2O4 | [MOL File]
2806031-94-5.mol | [Molecular Weight]
418.24 |
| Hazard Information | Back Directory | [Description]
NIC-0102 is an orally bioavailable proteasome inhibitor. NIC-0102 specifically prevents NLRP3 inflammasome activation but has no effect on NLRC4 or AIM2 inflammasomes. In vitro studies revealed that NIC-0102 induced the polyubiquitination of NLRP3, interfered with the NLRP3?ASC interaction, and blocked ASC oligomerization, thereby resulting in the inhibition of NLRP3 inflammasome activation. In addition, NIC-0102 also inhibited the production of pro-IL-1β. Importantly, NIC-0102 showed potent anti-inflammatory effects on DSS-induced ulcerative colitis model in vivo. |
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