| Identification | Back Directory | [Name]
1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE | [CAS]
288573-56-8 | [Synonyms]
KS0037
KS-0037 powder
Pharmaceutical Powder
tert-Butyl 4-(4-fluoroanilino)-1-
1,1-dimethylethyl ester CAS 288573-56-8
Boc-4- (4-FLUORO-PHENYLAMINO) -Piperidine
1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE
1-Piperidinecarboxylicacid CAS 288573-56-8
4-[(4-Fluorophenyl)Amino]Piperidine-1-Carboxylate
tert-butyl 4-(4-fluoroanilino)piperidine-1-carboxylate
High purity 4-[(4-fluorophenyl)amino]- CAS 288573-56-8
1-tert-Butoxycarbonyl-4-[(4-fluorophenyl)amino]piperidine
1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE Basic information
China Tert-Butyl 4- (4-fluoroanilino) Piperidine-1-Carboxylate
1-Piperidinecarboxylic acid, 4-[(4-fluorophenyl)amino]-, 1,1-dimethylethyl ester | [EINECS(EC#)]
200-533-0 | [Molecular Formula]
C16H23FN2O2 | [MDL Number]
MFCD07785990 | [MOL File]
288573-56-8.mol | [Molecular Weight]
294.36 |
| Chemical Properties | Back Directory | [Boiling point ]
400.4±40.0 °C(Predicted) | [density ]
1.159±0.06 g/cm3(Predicted) | [pka]
5.09±0.20(Predicted) | [InChI]
InChI=1S/C16H23FN2O2/c1-16(2,3)21-15(20)19-10-8-14(9-11-19)18-13-6-4-12(17)5-7-13/h4-7,14,18H,8-11H2,1-3H3 | [InChIKey]
TUYSUNKDSSHKHM-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCC(NC2=CC=C(F)C=C2)CC1 |
| Hazard Information | Back Directory | [Chemical Properties]
1-Boc-4-(4-Fluoro-Phenylamino)-Piperidine is a white solid.
 | [Uses]
1-BOC-4-(4-FLUORO-PHENYLAMINO)-PIPERIDINE is a heterocyclic derivative and can be used as a pharmaceutical intermediate. | [Preparation]
Sodium cyanoborohydride (661 mg, 10.0 mmol) was added to a methylene chloride solution (30 ml) of t-butyl 4-oxopiperidine-1-carboxylate (2.66 g, 13.1 mmol), 4-fluoroaniline (1.46 g, 13.1 mmol) and acetic acid (0.750 ml, 13.1 mmol), at 0°C, and stirring was carried out at room temperature for 15 hours. A saturated aqueous sodium hydrogencarbonate solution was added to the reaction solution, followed by extraction with ethyl acetate, and the extract was washed sequentially with water and saline, and dried over anhydrous sodium sulfate. The organic layer was concentrated and the resulting residue was washed with diisopropyl ether, followed by drying to afford 1-Boc-4-(4-Fluoro-Phenylamino)-Piperidine. Yield 80%.
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