| Identification | Back Directory | [Name]
N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide | [CAS]
289472-78-2 | [Synonyms]
Bortezomib USP IMP I
Bortezomib USP Impurity I
Bortezomib (EP) Impurity E
SR-Isomer, Bortezomib Impurity E
Bortezomib USP Related Compoud I
Bortezomib Impurity 2 (S,R-Isomer)
Bortezomib (1S,2R) Isomer Impurity
(R)-Hydroxy Des(boric Acid) BortezoMib
Bortezomib impurity 5/Bortezomib EP Impurity E
(S,R)-Bortezomib Hydroxyisopentyl Amide Analog
BortezoMib IMpurity 2 (SR-IsoMer, EP IMpurity E)
Bortezomib Impurity 2 (SR-Isomer, Bortezomib Impurity E)
(N-[(1R)-1-hydroxy-3-Methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninaMide
N-[(1S)-2-[[(1R)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]pyrazin
N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
N-[(1S)-2-[[(1R)-1-Hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide
2-PyrazinecarboxaMide, N-[(1S)-2-[[(1R)-1-hydroxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]-
Bortezomib Related Compund I/ (S,R)-Bortezomib Hydroxyisopentyl Amide Analog (Bortezomib Hydroxy S,R-Isomer Impurity) | [Molecular Formula]
C19H24N4O3 | [MOL File]
289472-78-2.mol | [Molecular Weight]
356.42 |
| Chemical Properties | Back Directory | [Boiling point ]
672.0±55.0 °C(Predicted) | [density ]
1.199±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
11.90±0.46(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
(R)-Hydroxy Des(boric acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway. |
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