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29098-15-5

29098-15-5 Structure

29098-15-5 Structure
IdentificationBack Directory
[Name]

terofenamate
[CAS]

29098-15-5
[Synonyms]

Etoclofene
terofenamate
ethoxymethyl N-(2,6-dichloro-m-tolyl)-anthranilate
2-[(2,6-Dichloro-m-tolyl)amino]benzoic acid ethoxymethyl ester
2-(2,6-Dichloro-3-methylphenyl)aminobenzoic acid ethoxymethyl ester
2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid ethoxymethyl ester
[EINECS(EC#)]

249-434-4
[Molecular Formula]

C17H17Cl2NO3
[MDL Number]

MFCD00866138
[MOL File]

29098-15-5.mol
Chemical PropertiesBack Directory
[Melting point ]

73-74°
[density ]

1.3318 (rough estimate)
[refractive index ]

1.6140 (estimate)
Hazard InformationBack Directory
[Originator]

Etofen Ilfi,Lusofarmaco,Italy,1980
[Manufacturing Process]

10 g sodium salt of N-2,6-dichloro-m-tolylanthranilic acid, 3 ml chloromethyl ethyl ether and 80 ml dry acetone were refluxed for 12 hours on waterbath under stirring. The solid was filtered off, and the solution evaporated to dryness. The residue was dissolved in chloroform, washed with sodium carbonate solution, then with water until neutral. After drying on sodium sulfate, the solution was evaporated to dryness. The obtained product was recrystallized from 95% ethanol. Melting point 73°C to 74°C.
[Therapeutic Function]

Antiinflammatory, Analgesic
Safety DataBack Directory
[Toxicity]

LD50 in mice, rats (mg/kg): 918, 307 orally; 300, 274 i.p. (Chieli)
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