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ChemicalBook--->CAS DataBase List--->292618-32-7

292618-32-7

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292618-32-7 Structure

292618-32-7 Structure
IdentificationBack Directory
[Name]

ST1481
[CAS]

292618-32-7
[Synonyms]

ST1481
Lbq707
CPT 184
GIMATECAN
Unii-7kks9R192f
ST1481: GIMATECAN
LBQ707; ST1481; CPT 184
7-T-Butoxyiminomethylcamptothecin
7-[(E)-tert-butyloxyiminomethyl]-camptothecin
(4S)-11-((E)-((1,1-Dimethylethoxy)imino)methyl)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione
1H-Pyrano(3',4':6,7)indolizino(1,2-B)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-(o-(1,1-dimethylethyl)oxime), (C(E),4S)-
[Molecular Formula]

C25H25N3O5
[MDL Number]

MFCD06795143
[MOL File]

292618-32-7.mol
[Molecular Weight]

447.49
Chemical PropertiesBack Directory
[Boiling point ]

780.6±70.0 °C(Predicted)
[density ]

1.37±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

11.20±0.20(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07,GHS08,GHS06
[Signal word ]

Danger
[Hazard statements ]

H300-H335-H319-H351-H315
[Precautionary statements ]

P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Spectrum DetailBack Directory
[Spectrum Detail]

ST1481(292618-32-7)1HNMR
Hazard InformationBack Directory
[Biological Activity]

Gimatecan (ST1481) is a potent topoisomerase I inhibitor. It is an orally active camptothecin analog with antineoplastic activity.
[in vivo]

Gimatecan (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth.

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Animal Model: Athymic Swiss nude mice bearing HT1376 model
Dosage: 2 mg/kg
Administration: Treatment per os, every fourth day for four times
Result: Caused a marked tumor growth inhibition during treatment.
[target]

Topoisomerase I

[storage]

Store at -20°C
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