| Identification | Back Directory | [Name]
ST1481 | [CAS]
292618-32-7 | [Synonyms]
ST1481
Lbq707
CPT 184
GIMATECAN
Unii-7kks9R192f
ST1481: GIMATECAN
LBQ707; ST1481; CPT 184
7-T-Butoxyiminomethylcamptothecin
7-[(E)-tert-butyloxyiminomethyl]-camptothecin
(4S)-11-((E)-((1,1-Dimethylethoxy)imino)methyl)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione
1H-Pyrano(3',4':6,7)indolizino(1,2-B)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-(o-(1,1-dimethylethyl)oxime), (C(E),4S)- | [Molecular Formula]
C25H25N3O5 | [MDL Number]
MFCD06795143 | [MOL File]
292618-32-7.mol | [Molecular Weight]
447.49 |
| Chemical Properties | Back Directory | [Boiling point ]
780.6±70.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
11.20±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Gimatecan (ST1481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity[1]. | [Biological Activity]
Gimatecan (ST1481) is a potent topoisomerase I inhibitor. It is an orally active camptothecin analog with antineoplastic activity. | [in vivo]
Gimatecan (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth. < div class="cpd-mod-vv"> | Animal Model: | Athymic Swiss nude mice bearing HT1376 model | | Dosage: | 2 mg/kg | | Administration: | Treatment per os, every fourth day for four times | | Result: | Caused a marked tumor growth inhibition during treatment. | table> [target]
| [IC 50]
Topoisomerase I | [storage]
Store at -20°C | [References]
[1] Paola Ulivi, et al. Cellular Basis of Antiproliferative and Antitumor Activity of the Novel Camptothecin Derivative, Gimatecan, in Bladder Carcinoma Models. Neoplasia. 2005 Feb;7(2):152-61. DOI:10.1593/neo.04397 |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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Tags:292618-32-7
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