| Identification | Back Directory | [Name]
SR3335 | [CAS]
293753-05-6 | [Synonyms]
SR3335
ML-176
SR3335;ML176
ML-176;SR-3335
ML-176;SR 3335;SR-3335;ML176;ML 176
SR3335;ML-176;SR 3335;SR-3335;ML176;ML 176
SR 3335 (This product is only available in Japan.)
N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]thiophene-2-sulfonamide
N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-2-thiophenesulfonamide
2-Thiophenesulfonamide, N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-
hiophene-2-sulfonic acid [4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-aMide
Thiophene-2-sulfonic acid [4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-aMide
SR3335,Thiophene-2-sulfonic acid [4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-aMide | [Molecular Formula]
C13H9F6NO3S2 | [MDL Number]
MFCD02724814 | [MOL File]
293753-05-6.mol | [Molecular Weight]
405.336 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
insoluble in H2O; ≥87.4 mg/mL in EtOH; ≥88.8 mg/mL in DMSO | [form ]
solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles.1,2,3 SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM).4 It is without effect on RORβ, RORγ, farnesoid X receptor, or liver X receptor α. SR 3335 evokes RORα-dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis.4 | [Definition]
ChEBI: N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-thiophenesulfonamide is a sulfonamide. | [target]
RORα | [storage]
Store at -20°C |
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