| Identification | Back Directory | [Name]
N-(5-chloropyridin-2-yl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide | [CAS]
296771-07-8 | [Synonyms]
dCeMM2
N-(5-chloropyridin-2-yl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide | [Molecular Formula]
C16H11ClN6OS | [MOL File]
296771-07-8.mol | [Molecular Weight]
370.816 |
| Chemical Properties | Back Directory | [density ]
1.60±0.1 g/cm3(Predicted) | [solubility ]
Soluble to 50 mM in DMSO | [form ]
Solid | [pka]
10.25±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
dCeMM2 is a molecular glue degrader. Induces ubiquitination and degradation of cyclin K by eliciting an interaction of CDK12-cyclin K with a CRL4B ligase complex. dCeMM2 displays near-total degradation of protein at 2.5 μM within 2h. Cell-permeable. | [storage]
Store at -20°C |
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