| Identification | Back Directory | [Name]
H2N-PEG6-CH2COOtBu | [CAS]
297162-50-6 | [Synonyms]
NH2-PEG6-C1-Boc
NH2-PEG6-CH2COOtBu
H2N-PEG6-CH2COOtBu
NH2CH2CH2(OCH2CH2)5OCH2CO2-t-Bu
tert-butyl 20-amino-3,6,9,12,15,18-hexaoxaicosanoate | [Molecular Formula]
C18H37NO8 | [MDL Number]
MFCD31656899 | [MOL File]
297162-50-6.mol | [Molecular Weight]
395.488 |
| Hazard Information | Back Directory | [Biological Activity]
NH2-PEG6-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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