| Identification | Back Directory | [Name]
PTP Inhibitor III | [CAS]
29936-81-0 | [Synonyms]
PTP Inhibitor III
4-(bromoacetyl)phenoxyacetic acid
Acetic acid, 2-[4-(2-bromoacetyl)phenoxy]-
PTP Inhibitor III - CAS 29936-81-0 - Calbiochem
PTP Inhibitor III (4-(Bromoacetyl)phenoxyacetic Acid) | [Molecular Formula]
C10H9BrO4 | [MOL File]
29936-81-0.mol | [Molecular Weight]
273.08 |
| Chemical Properties | Back Directory | [storage temp. ]
= -70C | [solubility ]
Soluble in DMSO (25 mg/ml) | [form ]
White solid | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. |
| Hazard Information | Back Directory | [Description]
PTP inhibitor III (29936-81-0) inhibits a broad range of protein tyrosine phosphatases (PTPs). Binds covalently to the active site of the enzyme.1-2? Blocks SHP1-mediated dephosphorylation of TRPV1 in dorsal root ganglion neurons aggravating CFA-induced inflammatory pain.3 | [Uses]
PTP Inhibitor III is an α-haloacetophenone derivative that acts as a photoreversible covalent inhibitor of protein tyrosine phosphatases (PTPs). It binds the catalytic domain of SHP-1 (Ki = 184 μM) and covalently reacts with free thiols, a reaction that is reversible with irradiation (350 nm). PTP Inhibitor III is cell permeable and inhibits a broad range of PTPs.[Cayman Chemical] | [storage]
Store at -20°C | [References]
Kanda et al. (2006), Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase; J. Biol. Chem., 281 28518
Popov et al. (2009), Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction; Biochem. Biophys. Res. Commun., 389 1
Xiao et al. (2015), Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats; Pain, 156 597 |
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