| Identification | Back Directory | [Name]
RS 504393 | [CAS]
300816-15-3 | [Synonyms]
RS 504393
RS-504393; RS504393
RS504393 >=98% (HPLC)
6-Methyl-1'-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidi
6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro-[benzo[d][1,3]oxazine-4,4'-piperidin]
6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro-[benzo[d][1,3]oxazine-4,4'-piperidin]-2(
6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
6-Methyl-1'-(2-(5-Methyl-2-phenyloxazol-4-yl)ethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 6-Methyl-1'-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethyl]- | [Molecular Formula]
C25H27N3O3 | [MDL Number]
MFCD09038564 | [MOL File]
300816-15-3.mol | [Molecular Weight]
417.5 |
| Hazard Information | Back Directory | [Uses]
RS 504393 is a small molecule antagonist at the CC chemokine receptor 2. | [Uses]
RS504393 has been used in mass spectrometry. | [Definition]
ChEBI: 6-methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-2-spiro[1H-3,1-benzoxazine-4,4'-piperidine]one is a member of 1,3-oxazoles. | [Biological Activity]
Extremely selective CCR2 chemokine receptor antagonist (IC 50 values are 98 nM and > 100 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC 50 = 330 nM) and ischemia-reperfusion injury in kidneys. | [Biochem/physiol Actions]
RS504393 is a highly selective CCR2 chemokine receptor antagonist. RS504393 inhibits MCP-1 chemotaxis and ischemia-reperfusion injury in kidneys. | [storage]
Store at +4°C |
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