| Identification | Back Directory | [Name]
1,4-TRANS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE | [CAS]
301648-08-8 | [Synonyms]
UCB 35625
1,4-TRANS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE | [Molecular Formula]
C30H37Cl2N2O2.I | [MDL Number]
MFCD09971133 | [MOL File]
301648-08-8.mol | [Molecular Weight]
655.44 |
| Hazard Information | Back Directory | [Uses]
UCB 35625 is an antagonist of CCR1, which are receptors prevalent in chronic inflammatory processes. UCB 35625 displays antiarthritic activity and is also a selective antagonist of CCR3. | [Biological Activity]
Potent chemokine CCR1 and CCR3 receptor antagonist. Inhibits MIP-1 α -induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants (IC 50 values are 9.57 and 93.8 nM respectively). Antagonizes CCR3-mediated entry of HIV-1 isolate 89.6 into NP-2 cells (IC 50 = 57 nM). Isomer of J 113863 (1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidiniumiodide ). | [storage]
Store at -20°C |
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