| Identification | Back Directory | [Name]
N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide | [CAS]
301675-24-1 | [Synonyms]
IRAK-4 protein kinase inhibitor 2
Benzamide, N-1H-benzimidazol-2-yl-3-nitro-
3-nitro-N-(1H-benzoimidazol-2-yl)-benzamide
N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide
N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide-2 | [Molecular Formula]
C14H10N4O3 | [MDL Number]
MFCD01006950 | [MOL File]
301675-24-1.mol | [Molecular Weight]
282.254 |
| Hazard Information | Back Directory | [Biological Activity]
IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders[1].
IRAK-4 protein kinase inhibitor 2 (compound 1) also inhibits IRAK-1, with an IC50 of <10 μM[1]. | [References]
[1]. Powers JP, et, al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5. |
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Cool Pharm, Ltd
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SPIRO PHARMA
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Energy Chemical
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