ChemicalBook--->CAS DataBase List--->30315-93-6

30315-93-6

30315-93-6 Structure

30315-93-6 Structure
IdentificationBack Directory
[Name]

N,N-dimethylarginine
[CAS]

30315-93-6
[Synonyms]

N,N-dimethylarginine
Asymmetric dimethylarginine
L-Arg(Me,Me)-OH(asymmetrical), >97%
N(omega),N(omega)-dimethyl-L-arginine
L-Ornithine, N5-[(dimethylamino)iminomethyl]-
Arginine Impurity 12(N, N-Dimethyl-L-Arginine)
N5-[(Dimethylamino)iminomethyl]-L-ornithine, 97%
(S)-2-Amino-5-(3,3-dimethylguanidino)pentanoic acid
N,N-dimethylarginine, 2-amino-5-(3,3-dimethylguanidino)pentanoic acid L-Arg(Me, Me)-OH (asymmetrical)
[Molecular Formula]

C8H18N4O2
[MDL Number]

MFCD00038406
[MOL File]

30315-93-6.mol
[Molecular Weight]

202.25
Chemical PropertiesBack Directory
[Boiling point ]

340.8±52.0 °C(Predicted)
[density ]

1.23±0.1 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Sealed in dry,2-8°C
[solubility ]

DMF: 5 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): freely soluble
[form ]

A crystalline solid
[pka]

2.50±0.24(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

Metabolomics
[Definition]

ChEBI: A L-arginine derivative having two methyl groups both attached to the primary amino moiety of the guanidino group.
[General Description]

Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Asymmetric dimethylarginine is created in protein methylation, a common mechanism of post-translational protein modification. This reaction is catalyzed by an enzyme set called S-adenosylmethionine protein N-methyltransferases (protein methylases I and II). The methyl groups transferred to create ADMA are derived from the methyl group donor S-adenosylmethionine, an intermediate in the metabolism of homocysteine. (Homocysteine is an important blood chemical, because it is also a marker of cardiovascular disease). After synthesis, ADMA migrates into the extracellular space and then into blood plasma.
[storage]

Store at -20°C, stored under nitrogen
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