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304896-21-7

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304896-21-7 Structure

304896-21-7 Structure
IdentificationBack Directory
[Name]

SIRT2 Inhibitor, Inactive Control, AGK7
[CAS]

304896-21-7
[Synonyms]

AGK7
SIRT2 Inhibitor, Inactive Control, AGK7
2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-8-ylprop-2-enamide
2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-8-quinolinyl-
[Molecular Formula]

C23H13Cl2N3O2
[MOL File]

304896-21-7.mol
[Molecular Weight]

434.27
Chemical PropertiesBack Directory
[storage temp. ]

+2C to +8C
[solubility ]

≤0.5mg/ml in DMSO;0.2mg/ml in dimethyl formamide
[form ]

Yellow solid
Hazard InformationBack Directory
[Description]

AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. AGK7 is an inactive control to be used in experiments with AGK2. It differs from AGK2, structurally, only in the position of nitrogen in the quinoline group. AGK7 has IC50 values greater than 50 μM on SIRT1 and SIRT2 and greater than 5 μM on SIRT3.
[References]

[1]. outeiro tf, kontopoulos e, altmann sm, et al. sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of parkinson's disease. science. 2007 jul 27;317(5837):516-9.
[2]. cole pa. chemical probes for histone-modifying enzymes. nat chem biol. 2008 oct;4(10):590-7.
Spectrum DetailBack Directory
[Spectrum Detail]

SIRT2 Inhibitor, Inactive Control, AGK7(304896-21-7)1HNMR
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