| Identification | Back Directory | [Name]
Glyceryl monothioglycolate | [CAS]
30618-84-9 | [Synonyms]
Einecs 250-264-8
GLYCERYL THIOGLYCOLATE
Glycerylmonothioglycolate
GLYCEROLMONOTHIOGLYCOLATE
Glycerol monomercaptoacetate
MERCAPTOACETIC ACID GLYCERYL ESTER
Acetic acid, mercapto-, monoester with glycerol
Aceticacid,mercapto-,monoesterwith1,2,3-propanetriol
Mercaptoacetic acid monoester with 1,2,3-propanetriol
mercaptoacetic acid, monoester with propane-1,2,3-triol
Acetic acid, 2-mercapto-, monoester with 1,2,3-propanetriol | [EINECS(EC#)]
250-264-8 | [Molecular Formula]
C5H10O4S | [MDL Number]
MFCD00153007 | [MOL File]
30618-84-9.mol | [Molecular Weight]
166.2 |
| Chemical Properties | Back Directory | [Boiling point ]
244℃[at 101 325 Pa] | [density ]
1.315[at 20℃] | [vapor pressure ]
0.001Pa at 25℃ | [pka]
8.4[at 20 ℃] | [Water Solubility ]
1000g/L at 20℃ | [InChI]
InChI=1S/C5H10O4S/c6-1-4(7)2-9-5(8)3-10/h4,6-7,10H,1-3H2 | [Contact allergens]
It is an acid permanent-wave ingredient, which induces
contact dermatitis in hairdressers. | [InChIKey]
DOGJSOZYUGJVKS-UHFFFAOYSA-N | [SMILES]
C(O)(CO)COC(=O)CS | [LogP]
0.45 at 22℃ | [EPA Substance Registry System]
Acetic acid, mercapto-, monoester with 1,2,3-propanetriol(30618-84-9) |
| Hazard Information | Back Directory | [Hazard]
A mild skin and eye irritant | [Description]
Glyceryl monothioglycolate is an acid permanent wave
ingredient, which induces contact dermatitis in hairdressers.
| [Uses]
Glyceryl monothio-glycolate is a component in "acid" permanent waving formulations, mainly for use in hairdressing salons. | [Definition]
ChEBI: Glyceryl monothioglycolate is a thioglycolate ester resulting from esterification of thioglycolic acid with glycerol. As a component of developer solutions in permanent wave products, it is the second most frequent allergen in hairdressers and avoidance of acid permanent waves is mandatory. It has a role as an allergen. | [Flammability and Explosibility]
Nonflammable | [References]
[1] Lynne H. Morrison M.D. , Frances J. Storrs M.D. “Persistence of an allergen in hair after glyceryl monothioglycolate—containing permanent wave solutions.” Journal of the American Academy of Dermatology 19 1 (1988): Pages 52-59. |
| Questions And Answer | Back Directory | [Allergy symptoms]
Glyceryl mono thioglycolate has been recognized as a potential sensitizer and has been reported to cause allergic contact dermatitis in both hairdressers and clients. Hairdressers most commonly manifest their allergy as a hand dermatitis, whereas the clients most often have a dermatitis involving the scalp, face, ears, and neck. In preliminary patch testing, hair recently permanently woven with a solution containing glyceryl monothioglycolate produced positive results. These observations suggested that the permanent-waved hair may retain glyceryl monothioglycolate or a cross-reacting product. Positive reactions were seen in hair collected as long as 3 months after the permanent. This suggests that a glyceryl monothioglycolate-related allergen is retained in hair for up to 3 months after the permanent, which may explain the long-lasting dermatitis in clients sensitive to glyceryl monothioglycolate[1].
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