| Identification | Back Directory | [Name]
parsalmide | [CAS]
30653-83-9 | [Synonyms]
Parsal
MY-41-6
parsalmide
5-Amino-N-butyl-2-(2-propynyloxy)benzamide
5-Amino-N-butyl-2-(2-propyn-1-yloxy)benzamide
Benzamide, 5-amino-N-butyl-2-(2-propyn-1-yloxy)- | [EINECS(EC#)]
250-274-2 | [Molecular Formula]
C14H18N2O2 | [MDL Number]
MFCD00864361 | [MOL File]
30653-83-9.mol | [Molecular Weight]
246.3 |
| Chemical Properties | Back Directory | [Melting point ]
83-85℃ | [Boiling point ]
389.31°C (rough estimate) | [density ]
1.107 | [refractive index ]
1.5500 (estimate) | [pka]
pKa (aq soln, 20°) 4.6 ±0.03 |
| Hazard Information | Back Directory | [Originator]
Parsalmide,Shanghai Lansheng Corporation | [Definition]
ChEBI: Parsalmide is a member of benzamides. | [Manufacturing Process]
5-Acetylamino-2-acetoxybenzoyl chloride was obtained by reaction of 5acetylamino-2-acetoxy-benzoic acid with thionylchloride.
5-Acetylamino-N-butyl-2-hydroxybenzamide was produced in the result of treatment of 5-acetylamino-2-acetoxybenzoyl chloride with butylamine in the
presence of sodium hydroxide
5-Acetamino-N-(n-butyl)-2-propargyloxybenzamide was obtained by reaction of 5-acetylamino-N-butyl-2-hydroxybenzamide with propargylbromide in the presence of sodium, isopropyl alcohol and sulfuric acid.
28.8 g (0.1 mole) 5-acetamino-N-(n-butyl)-2-propargyloxybenzamide in 320 ml of 4 N sulfuric acid was heated, under stirring, at 90°-95°C for 2 h. The clear solution was cooled and its pH adjusted to 1 with 1 N NaOH; after filtering, further alkali was subsequently added until a pH of 10 was obtained. At this point the product was separated by filtration and recrystallized from ethanol at 60°C to give 16.6 g (a yield of 68%) of chromatographically pure 5-amino-N-(n-hutyl)-2-propargyloxybenzamide; melting point 85°-87°C.
| [Therapeutic Function]
Muscle relaxant, Antiinflammatory, Analgesic |
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| Company Name: |
ABI Chem
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| Tel: |
|
| Website: |
www.abichem.com |
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