313380-27-7

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313380-27-7 Structure

Identification	Back Directory
[Name] SALOR-INT L224693-1EA
[CAS] 313380-27-7
[Synonyms] FDI 6 FDI-6 >=98% (HPLC) FDI 6 - NCGC 00099374 SALOR-INT L224693-1EA FOXM1 Inhibitor III (FDI-6) 3-AMINO-N-(4-FLUOROPHENYL)-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(4-fluorophenyl)-6-(2-thienyl)-4-(trifluoromethyl)- 3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide 3-Amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid (4-fluoro-phenyl)-amide
[Molecular Formula] C19H11F4N3OS2
[MDL Number] MFCD01416826
[MOL File] 313380-27-7.mol
[Molecular Weight] 437.43

Chemical Properties	Back Directory
[Boiling point ] 533.7±50.0 °C(Predicted)
[density ] 1.562±0.06 g/cm3(Predicted)
[storage temp. ] 2-8°C
[solubility ] DMSO:64.34(Max Conc. mg/mL);147.09(Max Conc. mM)
[form ] powder (flocculent)
[pka] 10.24±0.70(Predicted)
[color ] white to beige

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H319
[Precautionary statements ] P280-P301+P312+P330-P305+P351+P338-P337+P313

Hazard Information	Back Directory
[Uses] FDI-6 is an inhibitor of FOXM1. FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation.
[Biochem/physiol Actions] Forkhead domain inhibitor-6 (FDI-6) is used to treat anaemia patients because of diminished red blood production. In Hep-2 cells, FDI-6 can stimulate cell death and also helps to prevent cell proliferation, invasion and migration.
[References] [1] Gormally MV, et al. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 2014 Nov 12;5:5165. DOI:10.1038/ncomms6165

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