| Identification | Back Directory | [Name]
2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- | [CAS]
313964-19-1 | [Synonyms]
HIF-2α-IN-3
HIF-2α-IN-3
N-(4-chloro-3-nitrophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- | [Molecular Formula]
C12H6ClN5O5 | [MOL File]
313964-19-1.mol | [Molecular Weight]
335.66 |
| Chemical Properties | Back Directory | [Boiling point ]
505.6±60.0 °C(Predicted) | [density ]
1.726±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 12.5 mg/mL (37.24 mM; Need ultrasonic) | [form ]
Solid | [pka]
-2.92±0.48(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 μM and a KD of 1.1 μM. Anticancer agent[1].
HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain[1]. | [storage]
Store at -20°C | [References]
[1]. Rogers JL, et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J Med Chem. 2013 Feb 28;56(4):1739-47. |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
http://www.weikeqi-biotech.com/ |
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