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313984-77-9

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313984-77-9 Structure

313984-77-9 Structure
IdentificationBack Directory
[Name]

6-[(1-NaphthalenylMethyl)thio]-9H-purine
[CAS]

313984-77-9
[Synonyms]

PU 02
PU-02; PU02
6-[(1-NaphthalenylMethyl)thio]-9H-purine
6-((Naphthalen-1-ylmethyl)thio)-7H-purine
9H-Purine, 6-[(1-naphthalenylmethyl)thio]-
6-(Naphthalen-1-ylmethylsulfanyl)-7H-purine
[Molecular Formula]

C16H12N4S
[MDL Number]

MFCD23381174
[MOL File]

313984-77-9.mol
[Molecular Weight]

292.36
Chemical PropertiesBack Directory
[storage temp. ]

Sealed in dry,2-8°C
[solubility ]

Soluble to 100 mM in DMSO
[form ]

Powder
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
Hazard InformationBack Directory
[Description]

PU 02 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with IC50 values ranging from 0.36 to 1.3 μM for human 5-HT3A, 5-HT3AB, 5-HT3AC, and 5-HT3AE in a FLIPR membrane potential assay using HEK293 cells expressing human recombinant receptors. It is selective for 5-HT3 over other Cys-loop containing receptors with IC50 values >100 μM for mouse, rat, and human nicotinic (nACh), human GABAA, and human glycine (Gly) receptors. PU 02 inhibits currents induced by 5-HT in COS-7 cells expressing human 5-HT3A (IC50 = 0.49 μM). PU 02 also reduces growth of HepG2 cells in a dose-dependent manner via induction of cell cycle arrest at the G2/M phase and apoptosis.
Spectrum DetailBack Directory
[Spectrum Detail]

6-[(1-NaphthalenylMethyl)thio]-9H-purine(313984-77-9)1HNMR
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