| Identification | Back Directory | [Name]
(Gly1,Ser3·22,Gln4·34,Thr6,Arg19,Tyr21,Ala23·31,Aib32)-Pancreatic Polypeptide (human) | [CAS]
313988-89-5 | [Synonyms]
PubChem ID: 90479787
(Gly1,Ser3·22,Gln4·34,Thr6,Arg19,Tyr21,Ala23·31,Aib32)-Pancreatic Polypeptide (human)
(Gly1,Gln4·16,Thr6·13,Tyr7,Asp10,Asn11,Pro14,Arg26,Met30,Ala31,Aib32)-Neuropeptide Y (huMan, rat)
(Gly1,Ser3middot22,Gln4middot34,Thr6,Arg19,Tyr21,Ala23middot31,Aib32)-Pancreatic Polypeptide (human)
H-Gly-Pro-Ser-Gln-Pro-Thr-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Ala-Aib-Arg-Gln-Arg-Tyr-NH2
Glycyl-L-prolyl-L-seryl-L-glutaminyl-L-prolyl-L-threonyl-L-tyrosyl-L-prolylglycyl-L-α-aspartyl-L-asparaginyl-L-alanyl-L-threonyl-L-prolyl-L-α-glutamyl-L-glutaminyl-L-methionyl-L-alanyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-seryl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-tyrosyl-L-isoleucyl-L-asparaginyl-L-methionyl-L-alanyl-2-methylalanyl-L-arginyl-L-glutaminyl-L-arginyl-L-tyrosinamide | [Molecular Formula]
C183H281N57O54S2 | [MDL Number]
MFCD03456490 | [MOL File]
313988-89-5.mol | [Molecular Weight]
4207.67 |
| Hazard Information | Back Directory | [Biological Activity]
cPP1-7,NPY19-23,Ala31,Aib32,Gln34 is a potent and selective neuropeptide YY5 receptor agonist with IC50 of 0.24 nM for hY5 receptor binding. It increases dietary intake. | [in vitro]
cPP1-7,NPY19-23,Ala31,Aib32,Gln34 has IC 50 s of 530 nM, >500 nM , 51 nM for binding to the hY 1 , hY 4 , hY 2 receptors. | [in vivo]
cPP1-7,NPY19-23,Ala31,Aib32,Gln34 induces a high amount of food intake in a dose-dependent manner in adult male rats weighing 340-400 g. | [target]
| hY 5 receptor < /p> 0.24 nM (IC 50 ) | hY 1 receptor 530 nM (IC 50 ) | hY 2 receptor >500 nM (IC 50 ) | hY 4 receptor 51 nM (IC 50 ) | | [storage]
Store at -20°C |
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