| Identification | Back Directory | [Name]
STF-62247 | [CAS]
315702-99-9 | [Synonyms]
ERROR
CS-2363
STF-62247
UV0364770
STF-62247 USP/EP/BP
STF-62247 (STF62247
Autophagy Inducer, STF-62247
STF-62247;STF62247;STF 62247
4-(pyridin-4-yl)-N-m-tolylthiazol-2-amine
N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolaMine
2-Thiazolamine, N-(3-methylphenyl)-4-(4-pyridinyl)-
N-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine
N-(3-Methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine
Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem | [EINECS(EC#)]
631-141-1 | [Molecular Formula]
C15H13N3S | [MDL Number]
MFCD01121974 | [MOL File]
315702-99-9.mol | [Molecular Weight]
267.35 |
| Chemical Properties | Back Directory | [Melting point ]
158-160℃ | [density ]
1.255 | [storage temp. ]
room temp | [solubility ]
DMSO: soluble26mg/mL | [form ]
solid | [color ]
Off-white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
STF-62247 (315702-99-9) specifically induces autophagic cell death in VHL (von Hippel-Lindau)-deficient renal carcinoma cells both in vitro (IC50=625 nM) and in vivo. Renal cell carcinoma cell lines were radiosensitized by induction of autophagy following treatment with STF-62247. Cell permeable | [Uses]
Autophagy Inducer, STF-62247 is selectively kills RCC cells that have lost VHL tumor suppressor activity. | [Definition]
ChEBI: N-(3-methylphenyl)-4-pyridin-4-yl-2-thiazolamine is a substituted aniline. | [in vitro]
in vitro study demonstrated that stf-62247 exhibited selectively cytotoxicity and tumor growth inhibitory activity towards wild-type vhl and vhl-deficient renal cell carcinoma (rcc) in a hif-independent manner with ic50 of 16 μm and 0.625 μm, respectively. in addion, stf-62247 also resulted in cell apoptosis by inducing acidification and increasing autophagy in vhl-deficient cells. [1] | [in vivo]
animal experiments for stf-62247 activity were performed according to institutional and national guidelines and approved by stanford university's administrative panel on laboratory animal care. based on an in vivo mouse model, it was found that intraperitoneal injection of stf-62247 at a dose of 8 mg/kg significantly inhibited tumor growth of vhl-deficient sn12c tumor cells. [1] | [IC 50]
stf-62247 inhibits tumor growth in wild-type vhl and vhl-deficient renal cell carcinoma (rcc) in a hif-independent manner with ic50 of 16 μm and 0.625 μm, respectively. | [References]
1) Turcotte et al. (2008), Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death; Autophagy, 4 944
2) Chan et al. (2008), Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics; Cell Cycle, 7 2987
3) Anbalagan et al. (2012), Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy; Radiother. Oncol., 103 388 |
|
|