| Identification | Back Directory | [Name]
4EGI-1 | [CAS]
315706-13-9 | [Synonyms]
4EGI-1
CS-1408
CS-1896
4EGI-1/4EGI1
4EGI-1, >=98%
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1
α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid
Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-
alpha-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitrobenzenepropanoic acid
2-((4-(3,4-Dichlorophenyl)thiazol-2(3H)-ylidene)hydrazono)-3-(2-nitrophenyl)propanoic acid
2-[[4-(3,4-dichlorophenyl)-4,5-dihydro-1,3-thiazol-2-yl]hydrazinylidene]-3-[2-(dihydroxyamino)phenyl]propanoic acid | [EINECS(EC#)]
2017-001-1 | [Molecular Formula]
C18H12Cl2N4O4S | [MDL Number]
MFCD28142689 | [MOL File]
315706-13-9.mol | [Molecular Weight]
451.29 |
| Chemical Properties | Back Directory | [Boiling point ]
668.9±65.0 °C(Predicted) | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≥22.56 mg/mL in DMSO | [form ]
Brown solid. | [pka]
0.89±0.41(Predicted) |
| Hazard Information | Back Directory | [Description]
In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation. A major step in initiation is the assembly of a large multiprotein complex that includes the cap-binding protein eIF4E and the multidomain adaptor protein eIF4G. 4EGI-1 is an inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM). It directly binds eIF4E, competitively inhibiting an association with eIF4G that is necessary for cap-dependent translation. 4EGI-1 prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis. Research with this inhibitor supports a role for normal eIF4E/eIF4G interaction in memory consolidation and excess interaction in autism spectrum disorders. 4EGI-1 also blocks translation in some viruses that do not require eIF4E or a cap structure for initiation. | [Uses]
Selective and cell permeable inhibitor of the interaction between the human eukaryotic translation initiation factors 4E (eIF4E) and 4G (eIF4G). | [Definition]
ChEBI: 4EGI-1 is a dichlorobenzene, a member of 1,3-thiazoles, a C-nitro compound, a monocarboxylic acid and a hydrazone. | [storage]
Store at -20°C | [References]
[1] moerke n j, aktas h, chen h, et al. small-molecule inhibition of the interaction between the translation initiation factors eif4e and eif4g. cell, 2007, 128(2): 257-267. |
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