| Identification | Back Directory | [Name]
3-nitro-N-(4-phenoxyphenyl)-benzamide | [CAS]
316146-57-3 | [Synonyms]
ICA-105574
3-nitro-N-(4-phenoxyphenyl)-benzamide
Benzamide, 3-nitro-N-(4-phenoxyphenyl)- | [Molecular Formula]
C19H14N2O4 | [MDL Number]
MFCD01596399 | [MOL File]
316146-57-3.mol | [Molecular Weight]
334.33 |
| Chemical Properties | Back Directory | [Boiling point ]
430.9±30.0 °C(Predicted) | [density ]
1.333±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: >20mg/mL | [pka]
11.76±0.70(Predicted) | [color ]
off-white to light tan | [InChI]
InChI=1S/C19H14N2O4/c22-19(14-5-4-6-16(13-14)21(23)24)20-15-9-11-18(12-10-15)25-17-7-2-1-3-8-17/h1-13H,(H,20,22) | [InChIKey]
GDWKBKTVROCPNZ-UHFFFAOYSA-N | [SMILES]
C(NC1=CC=C(OC2=CC=CC=C2)C=C1)(=O)C1=CC=CC([N+]([O-])=O)=C1 |
| Hazard Information | Back Directory | [Description]
ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2. ICA-105574 shifts the voltage dependence of Ptype inactivation to a very positive direction and removes the hERG channel from inactivation at physiological membrane potentials[1].
| [References]
[1] Mahoko Asayama . “Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts.” Journal of pharmacological sciences 121 1 (2013): Pages 1-8.
|
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
|