ChemicalBook--->CAS DataBase List--->328998-53-4

328998-53-4

328998-53-4 Structure

328998-53-4 Structure
IdentificationBack Directory
[Name]

inS3-54A18
[CAS]

328998-53-4
[Synonyms]

inS3-54A18
2H-Pyrrol-2-one, 3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl-
[Molecular Formula]

C23H16ClNO2
[MOL File]

328998-53-4.mol
[Molecular Weight]

373.83
Chemical PropertiesBack Directory
[Boiling point ]

630.5±55.0 °C(Predicted)
[density ]

1.363±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : ≥ 150 mg/mL (401.25 mM)
[form ]

Solid
[pka]

10.05±0.30(Predicted)
[color ]

Yellow to orange
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.
[in vivo]

inS3-54A18 (200?mg/kg, p.o.) inhibits tumor growth, metastasis and expression of STAT3 target genes in a mouse xenograft model of A549 cells[1].

[IC 50]

STAT3
[storage]

Store at -20°C
[References]

[1] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92. DOI:10.1038/onc.2015.215
[2] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92
Spectrum DetailBack Directory
[Spectrum Detail]

inS3-54A18(328998-53-4)1HNMR
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