| Identification | Back Directory | [Name]
5-TRANS U-46619 | [CAS]
330796-58-2 | [Synonyms]
5-TRANS U-46619
LQANGKSBLPMBTJ-YTQMDITASA-N
9,11-DIDEOXY-9ALPHA, 11ALPHA-METHANOEPOXY-PROSTA-5E,13E-DIEN-1-OIC ACID
5-Heptenoic acid, 7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-, (5E)- (9CI) | [Molecular Formula]
C21H34O4 | [MDL Number]
MFCD00216069 | [MOL File]
330796-58-2.mol | [Molecular Weight]
350.49 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
≤100mg/ml in ethanol;100mg/ml in DMSO;100mg/ml in dimethyl formamide;2mg/ml in PBS(pH7.2) | [form ]
solution in acetate. |
| Hazard Information | Back Directory | [Uses]
U-46619 is a TP receptor agonist that exhibits properties similar to Thromboxane A2, inducing platelet aggregation and vascular smooth muscle contraction. 5-trans U-46619 is a minor impurity (2-5%) which is variably present in most commercial preparations of U-46619. The biological activity of 5-trans U-46619 has rarely been tested separately from U-46619 itself. In the only case published to date, 5-trans U-46619 was found to be a about half as potent an inhibitor of Prostaglandin E synthase as the 5-cis version of U-46619.[Cayman Chemical] | [Biological Activity]
5-trans u-46619 is a minor impurity (2-5%) which variably exists in most commercial preparations of u-46619 [1]. u-46619 is a selective thromboxane a2 agonist involved in inducing platelet aggregation and vascular smooth muscle contraction [2].the biological activity of 5-trans u-46619 has been rarely tested separately from u-46619 itself. in the only case published to date, 5-trans u-46619 was found to be a about half as potent an inhibitor of prostaglandin e synthase as the 5-cis version of u-46619 [1]. thromboxane a2 (txa2) has been involved in the pathogenesis of airway hyperresponsiveness. txa2 is a type of thromboxane produced by activated platelets and shows prothrombotic properties. thromboxane a2 has also been known as a vasoconstrictor and is especially important during tissue injury and inflammation [3]. | [storage]
Store at -20°C | [References]
[1] quraishi o, mancini j a, riendeau d. inhibition of inducible prostaglandin e 2 synthase by 15-deoxy-δ 12, 14-prostaglandin j 2 and polyunsaturated fatty acids[j]. biochemical pharmacology, 2002, 63(6): 1183-1189.
[2] coleman, r. a.,humphrey, p.p.a.,kennedy, i., et al. comparison of the actions of u-46619, a prostaglandin h2-analogue, with those of prostaglandin h2 and thromboxane a2 on some isolated smooth muscle preparations. british journal of pharmacology 73, 773-778 (1981).
[3] svensson j, strandberg k, tuvemo t, et al. thromboxane a2: effects of airway and vascular smooth muscle[j]. prostaglandins, 1977, 14(3): 425-436. |
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