| Identification | Back Directory | [Name]
Aurora Kinase Inhibitor II | [CAS]
331770-21-9 | [Synonyms]
IUN-70219
Aurora kinase inhibitor-2
N-(4-((6,7-Dimethoxyquinazolin-4-yl)amino)phenyl)benzamide
inhibit,Aurora-A,Aurora kinase inhibitor2,Aurora Kinase,ATP-competitive,Aurora kinase inhibitor 2,Aurora kinase inhibitor-2,Aurora-B,Inhibitor | [Molecular Formula]
C23H20N4O3 | [MDL Number]
MFCD13191283 | [MOL File]
331770-21-9.mol | [Molecular Weight]
400.43 |
| Chemical Properties | Back Directory | [Boiling point ]
518.6±50.0 °C(Predicted) | [density ]
1.321±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMF:0.25(Max Conc. mg/mL);0.62(Max Conc. mM)
DMF:PBS(pH7.2) (1:2):0.33(Max Conc. mg/mL);0.82(Max Conc. mM)
DMSO:2.5(Max Conc. mg/mL);6.2(Max Conc. mM) | [form ]
A crystalline solid | [pka]
13.01±0.70(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A (IC50 = 0.39 μM). In MCF-7 cells, it blocks proliferation with an IC50 value of 1.25 μM. |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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