| Identification | Back Directory | [Name]
4-[(1E)-2-[[(4-CHLOROPHENYL)METHYL]SULFONYL]ETHENYL]-BENZOIC ACID | [CAS]
334969-03-8 | [Synonyms]
ON01210
Recilisib
Recilisib sodium
Recilisib sodium salt
Recilisib sodium(ON01210)
4-Chlorobenzyl-4-carboxystyryl sulfone
4-[(1E)-2-[[(4-CHLOROPHENYL)METHYL]SULFONYL]ETHENYL]-BENZOIC ACID
Benzoic acid, 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]ethenyl]- | [Molecular Formula]
C16H13ClO4S | [MOL File]
334969-03-8.mol | [Molecular Weight]
336.79 |
| Chemical Properties | Back Directory | [Boiling point ]
607.8±55.0 °C(Predicted) | [density ]
1.423±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 35.71 mg/mL (106.03 mM) | [form ]
Solid | [pka]
4.00±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Recilisib (ON 01210) is a radioprotectant, which can activate AKT, PI3K activities in cells[1]. | [Biological Activity]
Recilisib is a radioprotectant that activates the activity of AKT and PI3K in cells. | [in vivo]
Recilisib Sodium (500 mg/kg) significantly increases the rate of recovery and differentiation of primitive bone marrow myeloid progenitor cells in mice. It in combination with radiation reduces CFU numbers in mice, but the Recilisib Sodium-treated mice consistently retain a capability to form differentiated colonies. | [target]
| Akt | PI3K | [IC 50]
PI3K | [storage]
Store at -20°C | [References]
[1] Kang AD, et al. ON01210.Na (Ex-RAD) mitigates radiation damage through activation of the AKT pathway. PLoS One. 2013;8(3):e58355. DOI:10.1371/journal.pone.0058355 |
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Tags:334969-03-8
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