| Identification | Back Directory | [Name]
Propanoic acid, 2-hydroxy-, compd. with N-[(2E)-6,6-dimethyl-2-hepten-4-ynyl]-N-methyl-1-naphthalenemethanamine (1:1) | [CAS]
335276-86-3 | [Synonyms]
DRG-0286
Lamisil Krem
Terbinafine lactate
SF 86-327 hydrochloride
Propanoic acid, 2-hydroxy-, compd. with N-[(2E)-6,6-dimethyl-2-hepten-4-ynyl]-N-methyl-1-naphthalenemethanamine (1:1) | [Molecular Formula]
C24H31NO3 | [MOL File]
335276-86-3.mol | [Molecular Weight]
381.52 |
| Hazard Information | Back Directory | [Description]
Terbinafine is a synthetic allylamine antifungal, is used topically for skin infections. Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol and dichloromethane, soluble in ethanol, and slightly soluble in water. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion of squalene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability, causing fungal cell lysis. (last updated: 8/11/2016). |
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