| Identification | Back Directory | [Name]
Cuspin-1 | [CAS]
337932-29-3 | [Synonyms]
Cuspin-1
Cuspin-1 >=98% (HPLC)
Methanone, (5-bromo-3-pyridinyl)(4-methylphenyl)- | [Molecular Formula]
C13H10BrNO | [MDL Number]
MFCD00452965 | [MOL File]
337932-29-3.mol | [Molecular Weight]
276.129 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 25 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 16 mg/mL; Ethanol: 1 mg/mL | [form ]
A crystalline solid | [color ]
brown |
| Hazard Information | Back Directory | [Description]
The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation. | [Uses]
Cuspin 1 is used in cuspin-1 characterization and regulation of SMN protein via Ras signaling in spinal muscular atropy. |
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| Company Name: |
Lynnchem
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| Tel: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
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44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
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| Tel: |
(+86) 21 2033 8288 |
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http://www.sigmaaldrich.cn |
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