| Identification | Back Directory | [Name]
KETOTIFEN | [CAS]
34580-13-7 | [Synonyms]
hc20-511
HC 20-511
KETOTIFEN
Ketotifeno
idinylidene)-
Ketotifen base
hiophen-10-one
KETOTIFENFUMARATC
Ketotifen Fumaratic
Ketotifen Free Base
4,9-dihydro-4-(1-methyl-4-piperidinylidene)-10h-benzo(4,5)cyclohepta(1,2-b)t
10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one
10h-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one,4,9-dihydro-4-(1-methyl-4-piper
4-(1-methylpiperidin-4-ylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one
4-(1-Methyl-4-piperidinylidene)-4H-benzo[4,5]cyclohepta[1,2-d]thiophene-10(9H)-one
4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
4-(1-Methyl-4-piperidinylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one | [EINECS(EC#)]
252-099-7 | [Molecular Formula]
C19H19NOS | [MDL Number]
MFCD00599548 | [MOL File]
34580-13-7.mol | [Molecular Weight]
309.43 |
| Chemical Properties | Back Directory | [Melting point ]
152-153℃ | [Boiling point ]
488.9±45.0 °C(Predicted) | [density ]
1.236 | [storage temp. ]
Amber Vial, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly) | [form ]
Solid | [pka]
8.84±0.20(Predicted) | [color ]
Light Yellow to Orange | [InChI]
InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3 | [InChIKey]
ZCVMWBYGMWKGHF-UHFFFAOYSA-N | [SMILES]
C12C(=O)CC3=CC=CC=C3/C(=C3/CCN(C)CC/3)/C=1C=CS2 | [EPA Substance Registry System]
Ketotifen (34580-13-7) |
| Hazard Information | Back Directory | [Originator]
Zaditen,Wander,Switz.,1978 | [Uses]
Anti-asthmatic. | [Definition]
ChEBI: Ketotifen is an organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect. It has a role as a H1-receptor antagonist and an anti-asthmatic drug. It is an organosulfur heterocyclic compound, an organic heterotricyclic compound, a cyclic ketone, a member of piperidines, an olefinic compound and a tertiary amino compound. It is a conjugate base of a ketotifen(1+). | [Manufacturing Process]
3.07 g of iodine-activated magnesium shavings are covered with a layer of 25
cc of tetrahydrofuran, and approximately 1/10 of a solution of 17.7 g of 4-
chloro-1-methylpiperidine base in 70 cc of absolute tetrahydrofuran is added.
The Grignard reaction is initiated by the addition of a few drops of 1,2-
dibromoethane. The remaining 4-chloro-1-methylpiperidine solution is then
added dropwise to the magnesium at such a rate that the reaction mixture
boils continuously at reflux without external heating. Boiling at reflux is then
continued for 1 hour. 15.3 g of 10-methoxy-4H-benzo[4,5]cyclohepta[1,2-
b]thiophen-4-one are subsequently added portionwise at 20°C, within 40
minutes, with slight cooling. After stirring at 20°C for 1,5 hours, the reaction
solution is poured on a mixture of 180 g of ice and 20 g of ammonium
chloride. The free base is extracted with chloroform.
The chloroform solution is concentrated and the residue recrystallized from
270 cc of absolute ethanol. The pure 10-methoxy-4-(1-methyl-4-piperidyl)-
4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ol base, having a melting point of
194°C to 196°C, is obtained in this manner. Microanalysis corresponds with
the formula C20H23NO2S.
A mixture of 3.4 g of 10-methoxy-4-(1-methyl-4-piperidyl)-4H-benzo[4,5]
cyclohepta [1,2-b]thiophen-4-ol base and 40 cc of 3N hydrochloric acid is kept
in a boiling water bath at 95°C to 100°C for 1 hour. The mixture is
subsequently made alkaline with concentrated caustic soda solution at 20°C
while cooling, and the free base is extracted with chloroform. The chloroform
solution is concentrated, and the residue is recrystallized from ethanol/water
1:1. The pure 4-(1-methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta [1,2-b]
thiophen-10(9H)-one base, having a melting point of 152°C to 153°C, is
obtained in this manner. | [Brand name]
Zaditor (Novartis). | [Therapeutic Function]
Anti-asthmatic, Antihistaminic | [General Description]
Crystals (from ethyl acetate). | [Fire Hazard]
Flash point data for KETOTIFEN are not available. KETOTIFEN is probably combustible. | [Clinical Use]
Ketotifen is a potent, selective H1 antihistamine that also prevents release of transmitters
from mast cells. It is approved in the United States for topical use to prevent itching of the
eye because of allergic conjunctivitis, It is used as a systemic antiallergy agent in several
countries outside the United States for the treatment of seasonal allergic rhinitis, hay fever,
and asthma. Being structurally analogous to the cyproheptadine-like antihistamines,
differences in activity of the two enantiomers (atropisomers) has been noted, being
approximately six- to seven-fold in ligand displacement and rodent-based assays.
Ketotifen has been shown to stabilize mast cells and to inhibit degranulation of eosinophils.
Like olopatadine, it has been shown to interact with model membranes, stabilizing them by
interaction with phospholipids monolayers. | [Metabolism]
Undergoes hepatic first-pass metabolism to form inactive
metabolites which are mainly excreted in the urine |
|
| Company Name: |
Tetranov Biopharm
|
| Tel: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
| Company Name: |
parabiochem
|
| Tel: |
025-83453382-8005 |
| Website: |
www.parabiochem.cn |
|