| Identification | Back Directory | [Name]
N-(4-butylphenyl)-4-fluorobenzenesulfonamide | [CAS]
346692-04-4 | [Synonyms]
DC260126
DC260126 >=98% (HPLC)
DC260126;DC-260126 ;DC 260126
N-(4-butylphenyl)-4-fluorobenzenesulfonamide
Benzenesulfonamide, N-(4-butylphenyl)-4-fluoro- | [Molecular Formula]
C16H18FNO2S | [MDL Number]
MFCD00784423 | [MOL File]
346692-04-4.mol | [Molecular Weight]
307.38 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
DC260126 is a free fatty acid receptor 1 (FFAR1/GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid (Item Nos. 90150, 90260, 10009871, and 10006626, respectively) with IC50 values of 6.28, 5.96, 7.07, and 4.58 μM, respectively. At 10 mg/kg, it has been shown to inhibit glucose-stimulated insulin secretion, to reduce blood insulin levels, to improve insulin sensitivity, and to decrease the rate of pancreatic β-cell apoptosis in obese diabetic db/db mice. | [storage]
Store at -20°C | [References]
1) Hu?et al. (2009),?A novel class of antagonist for the FFAs receptor GPR40; Biochem. Biophys. Res. Commun.,?390?557
2) Zhang?et al. (2010),?DC260126, a small molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats; Biomed. Pharmacother.,?64?647
3) Sun?et al. (2013),?DC260126: a small molecule antagonist of GPR40 that protects against pancreatic β-cells dysfunction in db/db mice; PLoS One.,?8(6)?e66744
4) Wu?et al. (2012), Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis; J. Biochem,?113?1152 |
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