| Identification | Back Directory | [Name]
CYCLACILLIN (200 MG) | [CAS]
3485-14-1 | [Synonyms]
wy4508
Calthor
Vipicil
Wyvital
Vatracin
cyclapen
Citosarin
NSC 88789
CICLACILIN
vastcillin
ultracillin
Syngacillin
ciclacillin
ciclacillum
cyclacillin
CYCLACILLIN (200 MG)
CYCLACILLIN USP/EP/BP
aminocyclohexylpenicillin
(1-aminocyclohexyl)penicillin
CYCLACILLIN (200 MG) USP/EP/BP
Penicillin, (aminocyclohexyl)-
6-(1-Aminocyclohexylcarboxamido)penicillanic acid
6-(1-aminocyclohexanecarboxamido)penicillanicacid
(5β)-6α-(1-Aminocyclohexylcarbonylamimo)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-(1-aminocyclohexanecarboxamido)-3,3-dimethyl-7-oxo- (7CI, 8CI)
(2S-(2-a,5a,6b))-6-((1-Aminocyclohexyl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(1-aminocyclohexyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(1-aminocyclohexyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, [2S-(2a,5a,6b)]- | [EINECS(EC#)]
222-470-8 | [Molecular Formula]
C15H23N3O4S | [MDL Number]
MFCD00864980 | [MOL File]
3485-14-1.mol | [Molecular Weight]
341.43 |
| Chemical Properties | Back Directory | [Melting point ]
182-183° (anhydrate) (Hou, Poole); mp 156-158° (dec) (Alburn et al.) | [alpha ]
D25 +268° (water) | [Boiling point ]
649.6±55.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [solubility ]
Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
pK1, pK2 in water: 2.68, 7.50; in 50% dioxane: 4.16, 7.04(at 25℃) | [color ]
White to Off-White | [Water Solubility ]
32g/L(25 ºC) | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Originator]
UItracillin,Gruenenthal,W. Germany,1972 | [Uses]
Antibacterial. | [Uses]
Cyclacillin is an aminosalicylic semisynthetic penicillin; Antibiotic. | [Definition]
ChEBI: Cyclacillin is a penicillin. It has a role as an antibacterial drug. | [Manufacturing Process]
To 21.6 g (0.10 mol) of 6-aminopenicillanic acid (6-APA) and 213 ml of
methylene chloride in a dry 500 ml 3-neck flask fitted with stirrer,
thermometer, nitrogen inlet and reflux condenser with drying tube, 25.3 g
(0.25 mol) of triethylamine and 13.4 g (0.11 mol) of N,N-dimethylaniline were
added. After stirring at reflux for one hour, the mixture was cooled and 21.7 g
(0.20 mol) of trimethylchlorosilane was added dropwise at 12° to 15°C
The mixture was refluxed for 45 minutes, cooled under nitrogen, and 19.8 g
(0.10 mol) of 1-amino-1-cyclohexane-carboxylic acid chloride HCl was added
portionwise at -10°C over 20 minutes. The mixture was stirred for an
additional hour while the temperature rose to 20°C. The reaction mixture was
poured into 200 ml of cold water with stirring and the two-phase mixture
clarified by filtration. Dilute sodium hydroxide solution was added to the
filtrate at 5° to 10°C to pH 5.4.
After stirring overnight at room temperature, the crystalline product was
collected by filtration, washed with water and finally with acetone, and then
dried at 45°C; yield of dihydrate, 29.9 g or 79% of theory based on 6-APA;
iodometric assay, 922 mcg per mg; bioassay, 921 mcg per mg, as described
in US Patent 3,478,018.
| [Brand name]
Cyclapen-W (Wyeth). | [Therapeutic Function]
Antibacterial | [Antimicrobial activity]
The structure differs from other aminopenicillins in that the
benzene ring is completely saturated and the amino substituent
is attached directly to it instead of being linked to an
adjacent carbon atom. It is less active than ampicillin against
staphylococci, streptococci and H. influenzae, but is better
absorbed by mouth, peak plasma levels of 10–18 mg/L being
reached after a 500 mg oral dose. Its pharmacokinetic properties,
side effects and use resemble those of ampicillin. It has
limited availability. |
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