| Identification | Back Directory | [Name]
7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol | [CAS]
352693-80-2 | [Synonyms]
7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol | [Molecular Formula]
C21H15Cl2N3O | [MOL File]
352693-80-2.mol | [Molecular Weight]
396.269 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 62.5 mg/mL (157.72 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
MMRi62 is an MDM4-degrader and apoptosis inducer in leukemia cells. MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status. MMRi62 effectively induced apoptosis in p53 mutant, multidrug-resistant leukemia cells and patient samples in addition to p53 wild-type cells. In contrast, MMRi67 as a RING heterodimer disruptor and an enzymatic inhibitor of the MDM2-MDM4 E3 complex lacked MDM4-degrader activity and failed to induce apoptosis in these cells. | [storage]
4°C, protect from light |
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