ChemicalBook--->CAS DataBase List--->3543-74-6

3543-74-6

3543-74-6 Structure

3543-74-6 Structure
IdentificationBack Directory
[Name]

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
[CAS]

3543-74-6
[Synonyms]

Bendamustine USP RC C
Bendamustine Impurity 40
Bendamustine Dihydroxy Ester
Bendamustine Related Impurity 1
Bendamustine Related Compound C
5-[Bis(2-hydroxyethyl)amino]-1-meth
Bendamustine USP Related Compound C
ethyl 4-(5-(bis(2-hydroxyethyl)amino)
Bendamustine hydrochloride Intermediates 1
Bendamustine USP RC C /Bendamustine Impurity A
Bendamustin Impurity-A (USP related compound C)
[1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butano...
5-112-hydroxyethyl complex with -1-methyl-1H benzimizole-2-butyrate B chisel
5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-2-benziMidazolebutyric Acid Ethyl Ester
1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester
5-(bis(2-hydroxyethyl)amino)-1-methyl-1h-benzimidazole-2-butanoic acid ethyl est
Ethyl 4-(5-Bis(2-Hydroxy Ethyl)Amino-1-Methyl-1Hbenzo[D]Imidazole-2-Yl]Butanoate
ethyl 4-{5-[bis(2-hydroxyethyl)aMino]-1-Methyl-1H-1,3-benzodiazol-2-yl}butanoate
Ethyl-4-(5-(bis(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoate
Ethyl 4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyrate
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
4-[5-[Bis(2-hydroxyethyl)aMino]-1-MethylbenziMidazol-2-yl]butanoic acid ethyl ester
1H-Benzimidazole-2-butanoicacid, 5-[bis(2-hydroxyethyl)amino]-1-methyl-, ethyl ester
4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acidethylester
[1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester Bendamustine Related
[EINECS(EC#)]

680-672-5
[Molecular Formula]

C18H27N3O4
[MDL Number]

MFCD09840918
[MOL File]

3543-74-6.mol
[Molecular Weight]

349.42
Chemical PropertiesBack Directory
[Melting point ]

98-101°C
[Boiling point ]

580.6±50.0 °C(Predicted)
[density ]

1.21±0.1 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Store in freezer, under -20°C
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

14.26±0.10(Predicted)
[color ]

White to Brown
Safety DataBack Directory
[HS Code ]

2933998350
Hazard InformationBack Directory
[Chemical Properties]

Off-White to Light Tan Solid
[Uses]

[1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester_x000D_Bendamustine Related Impurity 1 (cas# 3543-74-6) is a compound useful in organic synthesis.
[Synthesis]

Stir and dissolve 5-amino-1-methyl-1H-2-benzimidazole butyric acid ethyl ester (60g, 0.23mol), 600mL water, and 300mL glacial acetic acid in a 2L reaction flask, and cool to -50, Add 120 mL of ethylene oxide, and control the temperature to complete the reaction. Adjust the pH of the potassium carbonate solution to 7.0-7.3, extract with dichloromethane 300 mL×3, combine the organic phases, wash with purified water 200 mL×3, dry with anhydrous magnesium sulfate, filter, and concentrate to obtain a brown solid. Then add 1200 mL of ethyl acetate and heat to 70-80° C. to dissolve, cool to room temperature to crystallize, filter and dry to obtain 63 g of light brown solid 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester with a purity of 99.3%. The yield was 78.5%. 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
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