| Identification | Back Directory | [Name]
15(R)-15-METHYL PROSTAGLANDIN F2ALPHA METHYL ESTER | [CAS]
35700-22-2 | [Synonyms]
QQCOAAFKJZXJFP-IFMFXUMGSA-N
15(R)-15-methyl Prostaglandin F2α methyl ester
15(R)-15-METHYL PROSTAGLANDIN F2ALPHA METHYL ESTER
9ALPHA,11ALPHA,15R-TRIHYDROXY-15-METHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID, METHYL ESTER
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, methyl ester, (5Z,9α,11α,13E,15R)- | [Molecular Formula]
C22H38O5 | [MDL Number]
MFCD01632740 | [MOL File]
35700-22-2.mol | [Molecular Weight]
382.53 |
| Chemical Properties | Back Directory | [solubility ]
DMF: >50 mg/ml (from PGE2 methyl es; DMSO: >50 mg/ml (from PGE2 methyl es; Ethanol: >50 mg/ml (from PGE2 methyl es; PBS pH 7.2: 5 mg/ml (from PGE2 methyl este |
| Hazard Information | Back Directory | [Description]
15(R)-15-methyl Prostaglandin F2α methyl ester (15(R)-15-methyl PGF2α methyl ester) is a lipid soluble prodrug form of 15(R)-15-methyl PGF2α with increased membrane permeability. Acid-catalyzed epimerization of 15(R)-15-methyl PGF2α methyl ester and hydrolysis of the ester converts it into the active 15(S)-15-methyl PGF2α .1,2 | [References]
1. Plaisted, S.M., DeZwaan, J., and Snider, B.G. High-performance liquid chromatographic determination of acid-catalyzed degradation products of methyl carboprost in a polymeric controlled-release device J. Chromatogr. 314,369-377(1984).
2. Hamberg, M., Zhang, L.Y., and Bergstr?m, S. On the pH-dependent degradation of 15(S)-15 methyl-prostaglandin F2α (Carboprost) Eur. J. Pharm. Sci. 3(1),27-38(1995). |
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