| Identification | Back Directory | [Name]
1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE | [CAS]
358780-14-0 | [Synonyms]
1-(6-(Trifluoromethyl)
1-(6-(Trifluoromethyl)pyridin-3-yl)
5-Acetyl-2-(trifluoromethyl)pyridine
[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE
5-Acetyl-2-(trifluoromethyl)pyridine 97+%
1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE
1-(6-(trifluoroMethyl)pyridine-3-yl)ethanone
ETHANONE, 1-[6-(TRIFLUOROMETHYL)-3-PYRIDINYL]-
1-[6-(Trifluoromethyl)pyridin-3-yl]ethan-1-one | [Molecular Formula]
C8H6F3NO | [MDL Number]
MFCD07375085 | [MOL File]
358780-14-0.mol | [Molecular Weight]
189.13 |
| Chemical Properties | Back Directory | [Boiling point ]
233.7±40.0 °C(Predicted) | [density ]
1.280±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
-1.24±0.22(Predicted) | [InChI]
InChI=1S/C8H6F3NO/c1-5(13)6-2-3-7(12-4-6)8(9,10)11/h2-4H,1H3 | [InChIKey]
NAUKVLRFGMDIAN-UHFFFAOYSA-N | [SMILES]
C(=O)(C1=CC=C(C(F)(F)F)N=C1)C |
| Hazard Information | Back Directory | [Uses]
1-(6-(Trifluoromethyl)pyridin-3-yl)ethanone can be used as novel GPR119 agonists. | [Synthesis]
To a solution of 2-trifluoromethyl-5-bromopyridine (5.0 g, 22 mmol) in Et2O (50 mL) was added sec-BuLi (0.91 M in cyclohexane, 24 mL, 22 mmol) at -78 °C. After 10 minutes of stirring, N,N-dimethylaminoacetamide (2.3 mL, 24 mmol) dissolved in Et2O (10 mL) was added drop wise. Stirring was continued at -78 °C for 1 h and then at rt over night. The reaction mixture was poured into water (100 mL) and the water phase was extracted with Et2O (3×100 mL). Combined organics were washed with water and brine and dried (MgSO4). After careful evaporation of the solvent, the crude was purified by column chromotography (SiO2, pentane/ether 9/1) to give 1-(6-(Trifluoromethyl)pyridin-3-yl)ethanone (2.3 g, 12 mmol, 54%) as a light yellow solid. 1H NMR (CDCl3) δ 9.26 (br s, 1H) 8.43 (br d, J=5.6 Hz, 1H) 7.83 (br d, J=7.2 Hz, 1H) 2.71 (s, 3H).
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