| Identification | Back Directory | [Name]
D-MANNOHEPTULOSE | [CAS]
3615-44-9 | [Synonyms]
Ai3-61577
Nsc 226836
MANNOHEPTULOSE
D-MANNOHEPTULOSE
Einecs 222-795-5
Mannoheptulose,D-
D-Mannoketoheptose
D-manno-2-heptulose
ALPHA-D-MANNOHEPTULOSE
D-Manno-heptulose (8ci)
D-MANNOHEPTULOSE USP/EP/BP
d-Manno-[UL-13C7]hept-2-ulose | [EINECS(EC#)]
222-795-5 | [Molecular Formula]
C7H14O7 | [MDL Number]
MFCD00037814 | [MOL File]
3615-44-9.mol | [Molecular Weight]
210.18 |
| Chemical Properties | Back Directory | [Melting point ]
148-150°C | [alpha ]
D20 +29° (c = 2 in H2O) | [Boiling point ]
628.0±55.0 °C(Predicted) | [density ]
1.645±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
Solid | [pka]
11.86±0.20(Predicted) | [color ]
White to Off-White | [Merck ]
13,4686 | [BRN ]
1726433 | [EPA Substance Registry System]
D-manno-2-Heptulose (3615-44-9) |
| Hazard Information | Back Directory | [Description]
D-Glucose is phosphorylated by glucokinase and three tissue-specific hexokinases to produce glucose-6-phosphate in humans. D-Mannoheptulose is a heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (Ki = 0.25 mM). It blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells. D-Mannoheptulose prevents the conversion of glucose to glucose-6-phosphate that can mediate the activation of the carbohydrate response element binding protein. By blocking glucose phosphorylation, D-mannoheptulose causes transient hyperglycemia in dogs when given at 1 g/kg but not at 8 mg/kg, although postprandial energy expenditure is increased at the lower dose. | [Chemical Properties]
White Solid | [Uses]
Mannoheptulose occurs naturally in avocado fruit. | [Definition]
ChEBI: D-keto-manno-heptulose is the open chain form of D-manno-heptulose. |
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