ChemicalBook--->CAS DataBase List--->362-29-8

362-29-8

362-29-8 Structure

362-29-8 Structure
IdentificationBack Directory
[Name]

propiomazine
[CAS]

362-29-8
[Synonyms]

CB-1678
Wy-1359
propiomazine
(±)-Propiomazine
propiomazine USP/EP/BP
1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
1-[10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]propan-1-one
1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}-1-propanone
1-Propanone, 1-[10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-
[EINECS(EC#)]

206-646-1
[Molecular Formula]

C20H24N2OS
[MDL Number]

MFCD00599569
[MOL File]

362-29-8.mol
[Molecular Weight]

340.48
Chemical PropertiesBack Directory
[Boiling point ]

bp0.5 235-245°
[density ]

1.137±0.06 g/cm3(Predicted)
[pka]

pKa 6.6(H2O) (Uncertain)
Safety DataBack Directory
[Hazardous Substances Data]

362-29-8(Hazardous Substances Data)
Hazard InformationBack Directory
[Uses]

1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone is used in the preparation of analgesics as well as maintaining its own analgesic effects whilst applied to various neurological diseases.
[Uses]

Propiomazine is used in the preparation of analgesics as well as maintaining its own analgesic effects whilst applied to various neurological diseases.
[Definition]

ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 2-(dimethylamino)propyl group at nitrogen atom and a propanoyl group at position 2.
[Brand name]

Largon (Baxter Healthcare).
[in vivo]

Propiomazine (0.2 mg/kg, nasal administration, rats) is quickly absorbed, followed by rapid reduction of the plasma concentrations[3].
Propiomazine (25 mg/kg, i.p., at 0 and 3 h after challenge) protects rats against CCl4-induced hepatic injury[4].
Propiomazine (0.31-20 mg/kg, i.v.) increases plasma prolactin concentrations in rats[5].

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