| Identification | Back Directory | [Name]
GALANIN (2-11) PORCINE, RAT | [CAS]
367518-31-8 | [Synonyms]
AR-M 1896
GALANIN (2-11)
Galanin (2-11) (AR-M 1896)
GALANIN (2-11) PORCINE, RAT
TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2
H-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-NH2 | [Molecular Formula]
C54H81N13O14 | [MDL Number]
MFCD05664726 | [MOL File]
367518-31-8.mol | [Molecular Weight]
1136.3 |
| Hazard Information | Back Directory | [Biological Activity]
binding ic50: 1.76 nm for rgalr2; 879 nm for hgalr1galanin is a 29-aa neuropeptide with a complex role in pain processing. galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution. three galanin receptors, galr1, galr2 and galr3, have been identified and cloned. ar-m1896 is a specific galanin r2 (galr2) agonist. | [in vitro]
additional removal of the glycine residue in position 1 resulted in ar-m1896 with almost unchanged galr2 affinity and functional activity, and 500-fold selectivity for galr2-rs over galr1-rs. this compound represents a truly galr2-selective galanin analog and, thus, could be used as a pharmacological tool to differentiate between these two receptors [1]. | [in vivo]
in normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. the same effect is seen with equimolar doses of ar-m1896 or ar-m961 (an agonist both at galr1 and galr2 receptors). in allodynic bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high ar-m961dose, whereas no effect was observed in the control or ar-m1896 group. no effect of either compounds was observed in nonallodynic bennett model rats [1]. | [storage]
Desiccate at -20°C | [References]
[1] liu hx, brumovsky p, schmidt r, brown w, payza k, hodzic l, pou c, godbout c, h?kfelt t. receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via galr1 and galr2 receptors. proc natl acad sci u s a. 2001 aug 14;98(17):9960-4. |
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