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371943-05-4

371943-05-4 Structure

371943-05-4 Structure
IdentificationBack Directory
[Name]

PI3-Kinase α Inhibitor 2
[CAS]

371943-05-4
[Synonyms]

Compound 15e
PI3-Kinase α Inhibitor 2
PI3-Kinase α Inhibitor 2
Compound 15e, 98.0+ % (HPLC)
PI3-Kinase .alpha. Inhibitor 2
PI 3-Kinase Inhibitor 2 B-0304
PI3-Kinase α Inhibitor 2 Exclusive
3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]Phenol
Phenol, 3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-
[Molecular Formula]

C16H15N3O2S
[MOL File]

371943-05-4.mol
[Molecular Weight]

313.37
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 30 mg/ml; DMF:PBS(pH 7.2) (1:3): 0.25mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml
[form ]

White to off-white solid.
Hazard InformationBack Directory
[Description]

PI3-Kinase α (PI3Kα) inhibitor 2 is an inhibitor of PI3K p110α (IC50 = 2 nM in an enzyme assay). It is selective for p110α over p110β, p110γ, and PI3K C2β (IC50s = 16, 660, and 220 nM, respectively). It also inhibits mammalian target of rapamycin (mTOR; IC50 = 49 nM). PI3Kα inhibitor 2 inhibits proliferation in A375 melanoma cells with an IC50 value of 0.58 μM.
[Definition]

ChEBI: PI3-Kinase alpha Inhibitor 2 is an organonitrogen heterocyclic compound, an organosulfur heterocyclic compound and an organic heterobicyclic compound.
[storage]

Store at -20°C
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