Identification | Back Directory | [Name]
PI3-Kinase α Inhibitor 2 | [CAS]
371943-05-4 | [Synonyms]
Compound 15e PI3-Kinase α Inhibitor 2 PI3-Kinase α Inhibitor 2 Compound 15e, 98.0+ % (HPLC) PI3-Kinase .alpha. Inhibitor 2 PI 3-Kinase Inhibitor 2 B-0304 PI3-Kinase α Inhibitor 2 Exclusive 3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]Phenol Phenol, 3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]- | [Molecular Formula]
C16H15N3O2S | [MOL File]
371943-05-4.mol | [Molecular Weight]
313.37 |
Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMF:PBS(pH 7.2) (1:3): 0.25mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml | [form ]
White to off-white solid. |
Hazard Information | Back Directory | [Description]
PI3-Kinase α (PI3Kα) inhibitor 2 is an inhibitor of PI3K p110α (IC50 = 2 nM in an enzyme assay). It is selective for p110α over p110β, p110γ, and PI3K C2β (IC50s = 16, 660, and 220 nM, respectively). It also inhibits mammalian target of rapamycin (mTOR; IC50 = 49 nM). PI3Kα inhibitor 2 inhibits proliferation in A375 melanoma cells with an IC50 value of 0.58 μM. | [Definition]
ChEBI: PI3-Kinase alpha Inhibitor 2 is an organonitrogen heterocyclic compound, an organosulfur heterocyclic compound and an organic heterobicyclic compound. | [storage]
Store at -20°C |
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