| Identification | Back Directory | [Name]
N-palMitoyl-1-deoxysphinganine (M18:0/16:0) | [CAS]
378755-69-2 | [Synonyms]
N-C16-deoxysphinganine
N-palMitoyl-1-deoxysphinganine (M18:0/16:0)
Hexadecanamide, N-[(1S,2R)-2-hydroxy-1-methylheptadecyl]-
N-PALMITOYL-1-DEOXYSPHINGANINE (M18:0/16:0);N-C16-DEOXYSPHINGANINE | [Molecular Formula]
C34H69NO2 | [MDL Number]
MFCD22416666 | [MOL File]
378755-69-2.mol | [Molecular Weight]
523.92 |
| Hazard Information | Back Directory | [General Description]
N-C16-deoxysphinganine Commonly referred to as 1-deoxydihydroceramide (1-deoxyDHCer), is the N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism. The N-acyl group can be 16, 20 and 24 carbon chain. N-acylsphinganines (dihydroceramides) are synthesized by the acylation of sphingoid bases in the presence of ceramide synthases (CerS). | [Biochem/physiol Actions]
N-acylsphinganines (dihydroceramides) levels are lower during ceramide synthase inhibition. They are intermediates of ceramide and dihydrosphingolipids synthesis. Treatment of MCF7 cancer cells with fenretinide alters sphingolipid metabolism. |
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