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381168-77-0

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381168-77-0 Structure

381168-77-0 Structure
IdentificationBack Directory
[Name]

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
[CAS]

381168-77-0
[Synonyms]

ML367
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)-
[Molecular Formula]

C19H12F2N4
[MOL File]

381168-77-0.mol
[Molecular Weight]

334.32
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: ≥ 125 mg/mL (373.89 mM)
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Biological Activity]

ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.
[in vitro]

ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.

Western Blot Analysis

< table class="zh_use_1">
Cell Line: HEK293T cells
Concentration: 0-40 μM in the presence or absence of 20 μM 5-Furd
Incubation Time: 16 hours
Result: Inhibited the increased ATAD5 protein levels induced by 5-Furd.
[target]

TargetValue
ATAD5
()
[storage]

Store at -20°C
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