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383418-30-2

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383418-30-2 Structure

383418-30-2 Structure
IdentificationBack Directory
[Name]

N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
[CAS]

383418-30-2
[Synonyms]

HPA-12
N-[(2R,4S)-1,4-Dihydroxy-4-phenylbutan-2-yl]dodecanamide
N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
Dodecanamide, N-[(1R,3S)-3-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]-
N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
[Molecular Formula]

C22H37NO3
[MOL File]

383418-30-2.mol
[Molecular Weight]

363.53
Chemical PropertiesBack Directory
[solubility ]

Chloroform: soluble; DMSO: soluble
[form ]

powder to crystal
[color ]

White to Almost white
[CAS DataBase Reference]

383418-30-2
Safety DataBack Directory
[HS Code ]

2924.29.7790
Hazard InformationBack Directory
[Description]

HPA-12 is a ceramide analog and inhibitor of ceramide transfer protein (CERT). It inhibits binding of a ceramide probe to the isolated steroidogenic acute regulatory protein-related lipid transfer (START) domain of CERT with an EC50 value of 4 μM in a TR-FRET assay. HPA-12 (2.5 μM) inhibits conversion of the fluorescent ceramide analog C5-DMB-Cer to C5-DMB-sphingomyelin in CHO and HeLa cells. It also inhibits sphingomyelin synthesis in wild-type, but not ATP-dependent ceramide transport-deficient, CHO cells when used at a concentration of 1 μM.
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