| Identification | Back Directory | [Name]
Abacavir Carboxylate | [CAS]
384380-52-3 | [Synonyms]
2269W
Abacavir Carboxylate
Abacavir Impurity 14
(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-ene-1-carboxylic acid
(1S,4R)-4-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enecarboxylic acid
(1S,4R)-4-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]-2-cyclopentene-1-carboxylic Acid
2-Cyclopentene-1-carboxylic acid, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)- | [Molecular Formula]
C14H16N6O2 | [MOL File]
384380-52-3.mol | [Molecular Weight]
300.32 |
| Chemical Properties | Back Directory | [Melting point ]
208-210°C (dec.) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) | [form ]
Solid | [color ]
Off-White to Pale Beige | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Description]
Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir . It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues. | [Chemical Properties]
Off-White Solid | [Uses]
A major metabolite of Abacavir | [Uses]
Abacavir Carboxylate (Abacavir - In House Impurity) is a major metabolite of Abacavir (A105000) in human urine and cerebrospinal fluid (1,2,3). | [Definition]
ChEBI: Abacavir 5'-carboxylic acid is a monocarboxylic acid oxidation product of abacavir, in which the C-5' hydroxymethyl group has been oxidised to a carboxy group. One of the two major metabolites of abacavir in humans (the other is the 5'-glucuronide, CHEBI:64189). It has a role as a metabolite. It is functionally related to an abacavir. |
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