| Identification | Back Directory | [Name]
MURISTERONE A | [CAS]
38778-30-2 | [Synonyms]
MURA
Muristerone
MURISTERONE A
Ecdysonic sterol
MURISTERONE A(P)
MURISTERONE A USP/EP/BP
MURISTERONE A, IPOMOEA SPP
5B, 7-CHOLESTENE-2B,3B,5A,11A,14,20,22-HEPTOL-6-ONE
2B,3B,5A,11A,14,20,22-HEPTAHYDROXY-5B-7-CHOLESTEN-6-ONE
2β,3β,5β,11α,14α,20R,22R-Heptahydroxycholest-7-en-6-one
(22R)-2β,3β,5,11α,14,20,22-Heptahydroxy-5β-cholest-7-en-6-one
MurA, 2β,3β,5β,11α,14α,20R,22R-Heptahydroxycholest-7-en-6-one
5BETA,7-CHOLESTENE-2BETA,3BETA,5ALPHA,11ALPHA,14,20,22-HEPTOL-6-ONE
(2β,3β,5β,11α,22R)-2,3,5,11,14,20,22-Heptahydroxycholest-7-en-6-one
2BETA,3BETA,5ALPHA,11ALPHA,14,20,22-HEPTAHYDROXY-5BETA,7-CHOLESTEN-6-ONE
2BETA,3BETA,5BETA,11ALPHA,14ALPHA,20R,22R-HEPTAHYDROXYCHOLEST-7-EN-6-ONE
(2beta,3beta,5beta,11alpha,22R)-2,3,5,11,14,20,22-Heptahydroxy-cholest-7-en-6-one
Cholest-7-en-6-one, 2,3,5,11,14,20,22-heptahydroxy-, (2beta,3beta,5beta,11alpha,22R)- | [Molecular Formula]
C27H44O8 | [MDL Number]
MFCD00056450 | [MOL File]
38778-30-2.mol | [Molecular Weight]
496.63 |
| Hazard Information | Back Directory | [Description]
Muristerone A is a natural analog of 20-hydroxyecdysone . It is an agonist of the ecdysteroid receptor (Kd = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A is used as an agonist in ecdysone-inducible gene expression systems in mammalian cells. However, it inhibits apoptosis in the human colon carcinoma cell line RKO by inducing the upregulation of Bcl-xL, suggesting limitations in its use in certain types of studies. | [Uses]
Muristerone A, an ecdysteroid, is widely used for the induction of ecdysteroid-dependent transcription in mammalian cells. | [Biological Activity]
Ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells. | [storage]
Store at -20°C |
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