| Identification | Back Directory | [Name]
Pyrazolam | [CAS]
39243-02-2 | [Synonyms]
formaty
Pyrazolam
Pyrazolam solution
8-Bromo-1-methyl-6-(2-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]be nzodiazepine
4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-bromo-1-methyl-6-(2-pyridinyl)-
8-Bromo-1-methyl-6-(pyridin-2-yl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C16H12BrN5 | [MDL Number]
MFCD26954579 | [MOL File]
39243-02-2.mol | [Molecular Weight]
354.2 |
| Chemical Properties | Back Directory | [Melting point ]
253-255 °C | [Boiling point ]
544.4±60.0 °C(Predicted) | [density ]
1.62±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml; Methanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
2.18±0.40(Predicted) | [InChI]
InChI=1S/C16H12BrN5/c1-10-20-21-15-9-19-16(13-4-2-3-7-18-13)12-8-11(17)5-6-14(12)22(10)15/h2-8H,9H2,1H3 | [InChIKey]
BGRWSFIQQPVEML-UHFFFAOYSA-N | [SMILES]
N12C(C)=NN=C1CN=C(C1=NC=CC=C1)C1=CC(Br)=CC=C12 |
| Hazard Information | Back Directory | [Description]
Pyrazolam is a benzodiazepine that has been abused recreationally.1 Like other benzodiazepines, pyrazolam has anxiolytic effects. Pyrazolam is a benzodiazepine that has been abused recreationally.1 Like other benzodiazepines, pyrazolam has anxiolytic effects.2 This product is intended for forensic and research purposes. | [Chemical Properties]
Pyrazolam is a benzodiazepine that has been abused recreationally. Like other benzodiazepines, pyrazolam has anxiolytic effects. Pyrazolam is a benzodiazepine that has been abused recreationally. Like other benzodiazepines, pyrazolam has anxiolytic effects. This product is intended for forensic and research purposes. | [Uses]
Pyrazolam is a benzodiazepine with an elimination half-life of about 17 hours and no detectable metabolites in human serum and urine; thus pyrazolam may go undetected without instrumental analytical techniques. | [Application]
Pyrazolam is a designer benzodiazepine that has been sold online as a 'legal high' or 'research chemical'. Since its emergence in Europe a few years ago, pyrazolam, along with other designer benzodiazepines, have increasingly been encountered in forensic case work. | [General Description]
Pyrazolam is a designer benzodiazepine that has been sold online as ′legal high′ or ′research chemical′. Since its emergence in Europe a few years ago, pyrazolam along with other designer benzodiazepines have increasingly been encountered in forensic case work. This Certified Spiking Solution? is suitable for a variety of GC/MS or LC/MS testing applications including for use in forensic analysis, urine drug testing, or clinical toxicology. | [Biological Activity]
Pyrazolam has structural similarities to alprazolam and bromazepam. Unlike other benzodiazepines, pyrazolam does not appear to undergo metabolism, instead being excreted unchanged in the urine.It is most selective for the α2 and α3 subtypes of the GABAA receptor.
| [Pharmacology]
Benzodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of pyrazolam on the nervous system.The anticonvulsant properties of benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors.Pyrazolam is most selective for the α2 and α3 receptor subtypes. It is excreted by the body unchanged thus not interacting with liver enzymes like other benzodiazepines, meaning that its use in people with reduced liver function may be safer. |
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