| Identification | Back Directory | [Name]
Propanoic acid, 2-[3-[[1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl]methyl]phenoxy]-, (2S)- | [CAS]
393794-17-7 | [Synonyms]
MLR24
MLR-24
MLR 24
Propanoic acid, 2-[3-[[1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl]methyl]phenoxy]-, (2S)- | [Molecular Formula]
C28H24F3NO6 | [MOL File]
393794-17-7.mol | [Molecular Weight]
527.49 |
| Chemical Properties | Back Directory | [Boiling point ]
585.5±50.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
RT | [solubility ]
Soluble in DMSO (up to 30 mg/ml) | [form ]
solid | [pka]
3.22±0.10(Predicted) | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| Hazard Information | Back Directory | [Description]
MRL-24 (393794-17-7) displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. MRL-24 is highly effective (30 nM) at blocking Cdk5-mediated phosphorylation of PPARγ. Cell permeable. | [References]
1) Choi?et al.?(2010),?Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by CDK5;? Nature,?466?451 |
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